Interferon-l rs12979860 genotype and liver fibrosis in viral and non-viral chronic liver disease
نویسندگان
چکیده
Mohammed Eslam1, Ahmed M. Hashem2, Reynold Leung1,3, Manuel Romero-Gomez4, Thomas Berg5,6, Gregory J. Dore7,8, Henry L.K. Chan9, William L. Irving10, David Sheridan11,12, Maria L. Abate13, Leon A. Adams14, Alessandra Mangia15, Martin Weltman16, Elisabetta Bugianesi13, Ulrich Spengler17, Olfat Shaker18, Janett Fischer5, Lindsay Mollison19, Wendy Cheng20, Elizabeth Powell21,22, Jacob Nattermann17, Stephen Riordan23, Duncan McLeod24, Nicola J. Armstrong25, Mark W. Douglas1, Christopher Liddle1, David R. Booth3, Jacob George1,*, Golo Ahlenstiel1,* & the International Hepatitis C Genetics Consortium (IHCGC)w
منابع مشابه
Polymorphism of IL-28B Gene (rs12979860) in HCV Genotype 1 Patients Treated by Pegylated Interferon and Ribavirin
Background: Nowadays, the immune response to hepatitis C (HCV) treatment has become a crucial issue mostly due to the interleukin 28B (IL-28B) polymorphism effects in chronic HCV patients. The aim of this study was to detect the polymorphism of IL-28B gene (rs12979860) in HCV genotype 1 patients treated with pegylated Interferon and Ribavirin. Methods...
متن کاملInterferon-λ rs12979860 genotype and liver fibrosis in viral and non-viral chronic liver disease
Tissue fibrosis is a core pathologic process that contributes to mortality in ~45% of the population and is likely to be influenced by the host genetic architecture. Here we demonstrate, using liver disease as a model, that a single-nucleotide polymorphism (rs12979860) in the intronic region of interferon-λ4 (IFNL4) is a strong predictor of fibrosis in an aetiology-independent manner. In a coho...
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Lambda interferons (IFNL, IFN-λ) are pro-inflammatory cytokines important in acute and chronic viral infection. Single-nucleotide polymorphisms rs12979860 and rs8099917 within the IFNL gene locus predict hepatitis C virus (HCV) clearance, as well as inflammation and fibrosis progression in viral and non-viral liver disease. The underlying mechanism, however, is not defined. Here we show that th...
متن کاملImpact of rs12979860 polymorphism on liver morphology in chronic HCV infection
AIM OF THE STUDY To determine distribution of rs12979860 genotypes, their correlations with viral load as well as inflammatory activity and stage of liver fibrosis in patients infected with HCV genotype 1. MATERIAL AND METHODS The study included 132 patients infected with HCV genotype 1b. Serum viral loads were obtained with the PCR method. Rs12979860 polymorphisms were determined by sequenci...
متن کاملIL28B polymorphisms influence stage of fibrosis and spontaneous or interferon-induced viral clearance in thalassemia patients with hepatitis C virus infection.
BACKGROUND Polymorphisms in the interleukin-28B are important determinants in the spontaneous and drug-induced control of hepatitis C virus infection. DESIGN AND METHODS We assessed the association of rs8099917 and rs12979860 polymorphisms with spontaneous viral clearance, severity of liver fibrosis, and response to interferon-monotherapy in 245 thalassemia major patients with hepatitis C vir...
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Pretreatment serum levels of interferon-γ-inducible protein-10 (IP-10, CXCL10) and dipeptidyl peptidase-4 (DPP IV) predict treatment response in chronic hepatitis C (CHC). The association between functional genetic polymorphisms of CXCL10 and DPP4 and treatment outcome has not previously been studied. This study aimed to determine the association between genetic variations of CXCL10 and DPP4 an...
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تاریخ انتشار 2015